From mmreturn@magnetdev.com Thu Nov 5 10:40:36 2009 Return-Path: Received: from mail132.magnetmail.net (mail132.magnetmail.net [209.18.70.132]) by smtp.XXXXXXX.XXX (8.14.3/8.14.3) with ESMTP id nA5IeY8C027579 for ; Thu, 5 Nov 2009 10:40:35 -0800 Message-Id: <200911051840.nA5IeY8C027579@smtp.XXXXXXX.XXX> Received: from MAGNETMAIL1 (172.16.132.1) by mail132.magnetmail.net id huce280ir20c for ; Thu, 5 Nov 2009 13:40:29 -0500 (envelope-from ) Date: Thu, 05 Nov 2009 13:40:29 -0500 From: editor@principalinvestigators.org To: Subject: Your Issue: November 5, 2009 X-Bps1: 4323802360 MIME-Version: 1.0 Content-Type: multipart/alternative; boundary="_NextPart_000_857695_2009115_13402941" X-Proofpoint-Virus-Version: vendor=fsecure engine=1.12.8161:2.4.5,1.2.40,4.0.166 definitions=2009-11-05_16:2009-10-29,2009-11-05,2009-11-05 signatures=0 X-Proofpoint-Spam-Details: rule=notspam policy=default score=0 spamscore=0 ipscore=0 phishscore=0 bulkscore=100 adultscore=0 classifier=spam adjust=0 reason=mlx engine=5.0.0-0908210000 definitions=main-0911050164 --_NextPart_000_857695_2009115_13402941 Content-Type: text/plain; charset="ISO-8859-1" Content-Transfer-Encoding: quoted-printable PI e-Alert weekly e-zine is delivered at no charge worldwide. Feel free to = share (mailto:?subject=3DPI e-ALERT weekly) this issue with friends and col= leagues. Subscribe Today (XXXXXXXwww.principalinvestigators.org/free_e_aler= t.php)! Grant Clinic Reader Question: We are in the process of applying for a grant to extend pr= omising preliminary results. But should we also include mention of some con= tradictory data we found? This would demonstrate we did extra hours of work= , but will it undercut our chances for funding? Expert Comments: As to the "extra" hours of work you put in, nobody cares. = Only results count.=20 The first purpose in presenting preliminary data is to demonstrate feasibil= ity and that you have the necessary expertise to carry out the procedures y= ou propose in the Research Methods section. I believe it doesn't matter if = you have some contradictory results, or even that the data you are describi= ng were collected for other purposes in a different study. The focus in thi= s section is not on the results per se, but on the fact that you were succe= ssfully able to collect and analyze the data.=20 But pilot data showing positive results, are potent evidence. They indicate= that you are on the right track. The reviewers will weight this heavily. T= here are subtleties to reporting these, however. The possible variations in= volve (1) primacy of the outcomes; (2) positive/null/negative results; and = (3) statistical power of your pilot study to detect effects. Here are the p= ossibilities:=20 View the remainder of the expert comments (XXXXXXXwww.principalinvestigator= s.org/newsDetail.php?Grant-Clinic-Contradictory-Data-4) Comments by William Gerin, Ph.D., Professor of Biobehavioral Health, Pennsy= lvania State University Author, Writing the NIH Grant Proposal: A Step-by-S= tep Guide, SAGE Books (2006) Agree? Disagree? Submit your comments (XXXXXXXwww.principalinvestigators.or= g/newsDetail.php?Grant-Clinic-Contradictory-Data-4#comments) =20 ??Preview of Next Week's Question?? Reader Question: The regional sales manager of an equipment manufacturer fr= om whom our lab has made large purchases has emailed that he would like to = take me and my grad students out to a nice dinner during the upcoming natio= nal meeting of our research specialty. We obviously are already good custom= ers. Should academics like us accept such? Why or why not? Also would it ma= tter if we were merely "prospective" customers instead of proven ones? =20 Submitt early-bird comments (XXXXXXXwww.principalin= vestigators.org/news.php) =20 Subscribe Today! (XXXXXXXwww.principalinvestigators.org/free_e_alert.php) =20 This issue was brought to you as a service by Principal Investigators Assoc= iation. 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Grant Clinic =0A =0A

Reader Question: =0AWe are in the process of applying for a grant to extend promising = preliminary results. But should we also include mention of some contradicto= ry data we found? This would demonstrate we did extra hours of work, but wi= ll it undercut our chances for funding?

=0A =0A

Expert Comments: =0AAs to the "extra" hours of work you put in, nobody cares. On= ly results count.

=0A =0A

The first purpose in p= resenting preliminary data is to demonstrate feasibility and that you have = the necessary expertise to carry out the procedures you propose in the Rese= arch Methods section. I believe it doesn't matter if you have some contradi= ctory results, or even that the data you are describing were collected for = other purposes in a different study. The focus in this section is not on th= e results per se, but on the fact that you were successfully able to collec= t and analyze the data.

=0A =0A

But pilot data showing= positive results, are potent evidence. They indicate that you are on the r= ight track. The reviewers will weight this heavily. There are subtleties to= reporting these, however. The possible variations involve (1) primacy of t= he outcomes; (2) positive/null/negative results; and (3) statistical power = of your pilot study to detect effects. Here are the possibilities: <= /p> =0A

View the re= mainder of the expert comments

=0A =0A

Comments by=0A = William Gerin, =0APh.D., Professor of Biobehavioral Health, Pennsylvani= a State University Author,=0A Writing the NIH Grant Proposal: A Step-by-= Step Guide, =0ASAGE Books (2006)

=0A

Agree? Disagree? Subm= it your comments
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??Preview of Next Week's Question??

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Reader Question: =0AThe regional sales manager of an equipment manufacturer from whom = our lab has made large purchases has emailed that he would like to take me = and my grad students out to a nice dinner during the upcoming national meet= ing of our research specialty. We obviously are already good customers. Sho= uld academics like us accept such? Why or why not? Also would it matter if = we were merely "prospective" customers instead of proven ones?


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