John Keana PATENTS - for Publications, click HERE.

1. Keana, J. F. W. "Proxyl Nitroxides as Spin Labels," US Patent No. 4,099,918 issued July 11, 1978.

2. Keana, J. F. W., Sonders, M., Weber, E. "Sigma Brain Receptors and Their Use," US Patent No. 4,709,094 issued November 24, 1987.

3. Keana, J. F. W. "Methods for Circumventing the Problem of Free Radical Reduction Associated with the Use of Stable Nitroxide Free Radicals as Contrast Agents for Magnetic Resonance Imaging," US Patent No. 4,863,717 issued September 5, 1989.

4. Weber, E.; Keana, J. F. W. "N,N'-Disubstituted Guanidines and Their Use as Excitatory Amino Acid Antagonists," US Patent No. 4,906,779 issued March 6, 1990.

5. Keana, J. F. W.; Barmettler, P.; Weber, E. "PCP Receptor Ligands and the Use Thereof," US Patent No. 5,011,834 issued April 30, 1991.

6. Weber, E.; Keana, J. F. W. "N,N'-Disubstituted Guanidines and Their Use as Excitatory Amino Acid Antagonists," US Patent No. 5,093,525 issued March 3, 1992.

7. Keana, J. F. W. "Amplifier Molecules for Enhancement of Diagnosis and Therapy," US Patent No. 5,135,737 issued August 4, 1992.

8. Weber, E.; Keana, J. F. W. "N,N'-Disubstituted Guanidines and Their Use as Excitatory Amino Acid Antagonists," US Patent No. 5,190,976 issued March 2, 1993.

9. Keana, J. F. W. "Amplifier Molecules for Diagnosis and Therapy Derived from 3,5-Bis[1-(3-amino-2,2-bis(aminomethyl)propyl)oxymethyl] Benzoic Acid," US Patent No. 5,252,317 issued October 12, 1993.

10. Weber, E.; Keana, J. F. W. "Tri- and Tetra-Substituted Guanidines and Their Use as Excitatory Amino Acid Antagonists," US Patent No. 5,262,568 issued November 16, 1993.

11. Keana, J. F. W.; Weber, E. "Substituted Amidines Having High Binding to the Sigma Receptor and the Use Thereof," US Patent No. 5,308,869 issued May 3, 1994.

12. Keana, J. F. W.; Weber, E. "Substituted Guanidines Having High Binding to the Sigma Receptor and the Use Thereof," US Patent No. 5,312,840 issued May 17, 1994.

13. Weber, E.; Keana, J. F. W. "Tri- and Tetra-Substituted Guanidines and Their Use as Excitatory Amino Acid Antagonists," US Patent No. 5,336,689 issued August 9, 1994.

14. Weber, E.; Keana, J. F. W. " Methods for Treating Hypertension with Disubstituted Guanidine Compounds," US Patent No. 5,385,946 issued January 31, 1995.

15. Keana, J. F. W. "Amplifier Molecules Derived from Diethylene Triaminepentaacetic Acid for Enhancement of Diagnosis and Therapy," US Patent No. 5,412,148 issued May 2, 1995.

16. Wybourne, M. N.; Keana, J. F. W.; Cai, S. X.; Yan, M.; Wu, J. "Sensors Employing Interference of Electromagnetic Waves Passing Through Waveguides Having Functionalized Surfaces," US Patent No. 5,465,151 issued November 7, 1995.

17. Weber, E.; Keana, J. F. W.; Cai, S. X. "1,2,3,4-Tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the Use Thereof ," US Patent No. 5,475,007 issued December 12, 1995.

18. Keana, J. F. W.; Guzikowski, A. P.; Nogales, D. F.; Cai, S. X. "Azepine Synthesis via a Diels-Alder Reaction," US Patent No. 5,476,933 issued December 19, 1995.

19. Keana, J. F. W.; Weber, E. "Substituted Guanidines Having High Binding to the Sigma Receptor and the Use Thereof," US Patent No. 5,478,863 issued December 26, 1995.

20. Keana, J. F. W.; Weber, E. "Substituted Guanidines Having High Binding to the Sigma Receptor and the Use Thereof," US Patent No. 5,502,255 issued March 26, 1996.

21. Weber, E.; Keana, J. F. W. "Glycine Receptor Antagonists and the Use Thereof," US Patent No. 5,514,680 issued May 7, 1996.

22. Keana, J. F. W.; Weber, E. "Substituted Amidines Having High Binding to the Sigma Receptor and the Use Thereof," US Patent No. 5,552,443 issued September 3, 1996.

23. Keana, J. F. W.; Weber, E. "Tri- and Tetra-Substituted Guanidines and Their Use as Excitatory Amino Acid Antagonists" US Patent No. 5,559,154 issued September 24, 1996.

24. Keana, J. F. W.; Martin, V.; Ralston, W. H. "Dendritic Amplifier Molecules having Multiple Terminal Active Groups Stemming from a Benzyl Core Group," US Patent No. 5,567,411 issued October 22, 1996.

25. Keana, J. F. W.; Weber, E. "Substituted Guanidines Having High Binding to the Sigma Receptor and the Use Thereof," US Patent No. 5,574,070 issued November 12, 1996.

26. Keana, J. F. W.; Wybourne, M. N.; Cai, S. X.; Yan, M. "Chemical Functionalization of Surfaces," US Patent No. 5, 580,697 issued December 3, 1996.

27. Keana, J. F. W.; Wybourne, M. N.; Cai, S. X.; Yan, M. "Chemical Functionalization of Surfaces," US Patent No. 5, 582,955 issued December 10, 1996.

28. Yan, M.; Keana, J. F. W.; Wybourne, M. N.; Sevrain, C. J. P. "Molecularly Imprinted Materials, Method for Their Preparation and Devices Employing Such Materials," US Patent No. 5,587,273 issued December 24, 1996.

29. Cai, S. X.; Keana, J. F. W.; Weber, E. "Glycine Receptor Antagonist Pharmacophore," US Patent No. 5,597,922 issued January 28, 1997.

30. Keana, J. F. W.; Weber, E. "Substituted Guanidines Having High Binding to the Sigma Receptor and the Use Thereof," US Patent No. 5,604,228 issued February 18, 1997.

31. Keana, J. F. W.; Cai, S. X.; Weber, E. "8-Aza, 6-Aza and 6,8-Diaza-1,4-dihydroquinoxaline-2,3-diones and the Use Thereof as Antagonists for the Glycine/NMDA Receptor," US Patent No. 5,620,978 issued April 15, 1997.

32. Weber, E.; Keana, J. F. W. "Glycine Receptor Antagonists and the Use Thereof," US Patent No. 5,620,979 issued April 15, 1997.

33. Weber, E.; Keana, J. F. W. "Glycine Receptor Antagonists and the Use Thereof," US Patent No. 5,622,952 issued April 22, 1997.

34. Keana, J. F. W.; Weber, E.; Cai, S. X. "4-Hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the Use Thereof as Excitatory Amino Acid and Glycine Receptor Antagonists," US Patent No. 5,622,965 issued April 22, 1997.

35. Cai, S. X.; Kher, S.; Weber, E.; Keana, J. F. W. "Alkyl, Azido, Alkoxy, and Fluoro-Substituted and Fused Quinoxalinediones and the Use Thereof as Glycine Receptor Antagonists," US Patent No. 5,631,373 issued May 20, 1997

36. Weber, E.; Keana, J. F. W.; Cai, S. X. "1,2,3,4- Tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the Use Thereof, " US Patent No. 5,652,368 issued July 29, 1997.

37. Keana, J. F. W.; Weber, E. "Tri- and Tetra-Substituted Guanidines and Their Use as Excitatory Amino Acid Antagonists," US Patent No. 5,637,622 issued June 10, 1997.

38. Keana, J. F. W.; Weber, E. "PCP Receptor Ligands and the Use Thereof," US Patent No. 5,688,789 issued November 18, 1997.

39. Keana, J. F. W.; Guzikowski, Anthony P.; Nogales, Daniel F.; Cai, Sui Xiong, "Azepine Compounds," US Patent No. 5,708,168 issued January 13, 1998.

40. Weber, E.; Keana, J. F. W. "Tri- and Tetra-Substituted Guanidines and Their Use as Excitatory Amino Acid Antagonists," US Patent No. 5,767,162 issued June 16, 1998.

41. Weber, E.; Keana, J. F. W. "Tri- and Tetra-Substituted Guanidines and Their Use as Excitatory Amino Acid Antagonists," US Patent No. 5,798,390 issued August 25, 1998.

42. Keana, J. F. W.; Cai, S. X.; Martin, V. V.; Zhou, Z. -L.; Navratil, J. M. "Aza and Aza (N-Oxy) Analogs of Glycine/NMDA Receptor Antagonists," US Patent No. 5,801,183 issued September 1, 1998.

43. Yan, M.; Keana, J. F. W.; Karapetrov, G.; Sevrain, C. J.-P.; Wybourne, M. N. "Methods for Functionalizing and Coating Substrates and Devices made According to the Methods," US Patent No. 5,830,539 issued November 3, 1998.

44. Cai, S. X.; Keana, J. F. W.; Weber, E. "8-Aza, 6-Aza and 6,8-Diaza-1,4-dihydroquinoxaline-2,3-diones and the Use Thereof as Antagonists for the Glycine/NMDA Receptor," US Patent No. 5,863,916 issued January 26, 1999.

45. Cai, S. X.; Kher, S.; Weber, E.; Keana, J. F. W. "Alkyl, Azido, Alkoxy, and Fluoro-Substituted and Fused Quinoxalinediones and the Use Thereof as Glycine Receptor Antagonists," US Patent No. 5,977,107 issued November 2, 1999.

46. Weber, E.; Keana, J. F. W.; Barmettler, P "PCP Receptor Ligands and the Use Thereof," US Patent No. 6,017,910 issued January 25, 2000.

47. Yan, M.; Keana, J. F. W. "Chemical functionalization of surfaces," US Patent No. 6,022,597 issued February 8, 2000.

48. Bigge, C. F.; Keana, J. F. W.; Cai, S. X.; Weber, E.; Woodward, R.; Lan, N. C.; Guzikowski, A. P. "2-Substituted Piperidine Analogs and Their Use as Subtype Selective NDMA Receptor Antagonists," US Patent No. 6,124,317 issued September 26, 2000.

49. Bigge, C. F.; Yuen, P. -W.; Cai, S. X.; Weber, E.; Woodward, R.; Lan, N. C.; Zhou, Z.-L.; Keana, J. F. W.; Guzikowski, A. P. "4-Substituted Piperidine Analogs and Their Use as Subtype Selective NDMA Receptor Antagonists," US Patent No. 6,124,323 issued September 26, 2000.

50. Bigge, C. F.; Wright, J.; Cai, S. X.; Weber, E.; Woodward, R.; Lan, N. C.; Zhou, Z. -L.; Keana, J. F. W. "4-Substituted Piperidine Analogs and Their Use as Subtype Selective NDMA Receptor Antagonists," US Patent No. 6,130,234 issued October 10, 2000.

51. Cai, S. X.; Weber, E.; Keana, J. F. W.; Kher, S. "Alkyl, azido, alkoxy and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonist," US Patent No. 6,147,075, Issued November 14, 2000.

52. Keana, J. F. W.; Cai, S. X.; Guastella, J.; Yang, W.; Drewe, J. A. "Dipeptide Apoptosis Inhibitors and the Use Thereof," US Patent No. 6,184,210, Issued February 2, 2001.

53. Bigge, C. F.; Araldi, G. L.; Cai, S. X.; Guzikowski, A. P.; Lamunyon, D.; Lan, N. C.; Zhou, Z. -L.; Keana, J. F. W. “Subtype-selective NMDA receptor ligands and the Use Thereof,” US Patent No. 6,218,404, Issued April 17, 2001.

54. Cai, S. X.; Weber, W.; Keana, J. F. W.; Kher, S. "Substituted fused quinoxalinediones and their use as glycinemreceptor antagonists," US Patent No. 6,251,903, Issued, June 26, 2001.

55. Weber; E.; Keana; J. F. W. "Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists," US Patent No. 6,251,948, Issued, June 26, 2001

56. Cai, S. X.; Keana, J. F. W.; Drewe, J. A.; Zhang, H. -Z. "Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof," US Patent No. 6,335,429, Issued, January 1, 2002.

57. Weber; E.; Cai; S. X.; Keana; J. F. W.; Drewe; J. A.; Zhang; H. –Z. "Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof, " US Patent No. 6,342,611, Issued, January 29, 2002.

58. Bigge, C. F.; Wright, J.; Cai, S.X.; Weber, E.; Woodward, R.; Lan, N. C.; Zhou, Z.-L.; Keana, J. F. W. "4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists," US Patent No. 6,448,270, Issued, September 10, 2002.

59. Wang, Y.; Cai, S. X.; Lan, N. C.; Keana, J. F. W.; Ilyin, V. I.; Weber, E. “Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof,” US Patent No. 6,458, 843, Issued October 1, 2002.

60. Bigge, C. F.; Araldi, G. L.; Cai, S. X.; Guzikowski, A. P.; Lamunyon, D.; Lan, N. C.; Zhou; Z.-L.; Keana, J. F. W. “Subtype-selective NMDA receptor ligands and the use thereof,” US Patent No. 6,534,522 , Issued, March 18, 2003.

61. Bigge, C. F.; Keana, J. F. W.; Cai, S. X.; Weber, E; Woodward, R.; Lan, N. C.; Guzikowski, A. P. “2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists,” US Patent No. 6,534,525, Issued, March 18, 2003.

62. Keana, J. F. W.; Cai, S. X.; Guastella, J.; Yang, W.; Drewe, J. A.; Weber, E. "Dieptide apoptosis inhibitors and the use thereof," US Patent No. 6,596,693 B1, Issued, July 22, 2003.

63. Wang, Y.; Cai, S. X.; Lan, N. C.; Keana, J. F. W.; Ilyin, V. I.; Weber, E. "Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof," US Patent No. 6,613,803, Issued, September 2, 2003.

64. Wang, Y.; Cai, S. X.; Keana, J. F. W. “Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof,” US Patent No. 6,638,947, Issued, October 28, 2003.

65. Konkoy, C. S.; Fick, D. B.; Cai, S. X.; Lan, N. C.; Keana, J. F. W. “Substituted 5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyrans and benzothiopyrans and the use thereof as potentiators of AMPA,” US Patent No. 6,680,332, Issued, January 20, 2004.

66. Yang, Y.; Cai, S. X.; Lan, N. C.; Keana, J. F. W.; Ilyin, V. I.; Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof,” US Patent No. 6,696,442, Issued February 24, 2004.

67. Weber, E.; Cai, S. X.; Keana, J. F. W.; Drewe, J. A.; Zhang, H.-Z. “Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof,” US Patent No. 6,759,207, Issued July 6, 2004.

68. Konkoy, C. S.; Fick, D. B.; Cai, S. X.; Lan, N. C.; Keana, J. F. W. “Substituted 5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyrans,” US Patent No. 6,800,657, Issued October 5, 2004.

69. Keana, J. F. W.; Cai, S. X.; Guastella, J.; Yang, W.; Drewe, J. A.; Weber, E. „Dipeptide apotosis inhibitors and the use thereof, US Patent No. 6,949,516, Issued September 27, 2005.

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