It has been a classical question which manifolds admit Riemannian metrics with positive scalar curvature. A closed manifold is called aspherical if it has contractible universal cover. It has been conjectured since the 80s that all closed aspherical manifolds do not admit metric with positive scalar curvature. By works of Gromov-Lawson, Chodosh-Li, Gromov, and Chodosh-Li-Liokumovich, for n = 3, 4, 5, if a closed n-manifold M admits a map of nonzero degree to a closed aspherical n-manifold, then M does not admit a metric with positive scalar curvature. We prove for n = 3,4,5 that the connected sum of a closed aspherical n-manifold with an arbitrary non-compact manifold does not admit a complete metric with nonnegative scalar curvature. In particular, a special case of our result answers a question of Gromov. More generally, for n=3,4,5, we give a partial classification result of complete n-manifolds with positive scalar curvature and prove that no complete n-manifold with a non-zero degree map to a closed aspherical n-manifold can have positive scalar curvature. This result confirms the validity of Gromov's non-compact domination conjecture for closed aspherical manifolds of dimensions 3, 4, and 5. This is joint work with Jianchun Chu and Jintian Zhu.