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Director, Materials Science
Institute
Hutchison Lab
B.S., University of Oregon, 1986. Ph.D., Stanford University, 1991 (James P. Collman). Postdoctoral: University of North Carolina at Chapel Hill, 1992–94 (Royce W. Murray). Honors and Awards: Phi Beta Kappa; Franklin Veatch Fellowship, Stanford 1987–89; Centennial Teaching Assistant Award, Stanford, 1990; NSF Postdoctoral Fellow, 1992–94; Camille and Henry Dreyfus New Faculty Award, 1994; NSF CAREER Award, 1997; Alfred P. Sloan Research Fellow, 1999; Camille Dreyfus Teacher-Scholar, 1999; Oregon Academy of Science Outstanding Teacher of Science and Mathematics in Higher Education, 2003, University of Oregon Fund for Faculty Members Excellence Award, 2007. At Oregon since 1994.
Principal Research Interests
The Hutchison lab focuses on molecular-level design and synthesis of functional
materials, including ligands, surfaces and low-dimensional nanostructures.
We design structures to exhibit a desired function and test the efficacy
of the new materials for specific applications. To prepare functional nanostructures
and extended materials we synthesize functionalized organic and inorganic
chemical building blocks that are designed to assemble into organized structures
such as films, lines or devices. We then strive to understand how the structure
of the building blocks influences the assembly’s structure, reactivity,
stability, and electronic properties. Our designs for new processes and
materials draw heavily on the principles of green (environmentally-friendly)
chemistry.
Functionalized Gold Nanoparticles and Nanoparticle Arrays
Many applications in nanoscience, ranging from those in medicine to nanoelectronics,
will make use of specifically functionalized nanoparticles and/or nanoparticle
arrays. We investigate new synthetic methods that permit us to tune the
properties of nanoparticles and develop more efficient, greener approaches
to nanoparticle synthesis/manufacture. Diverse libraries of nanoparticles
prepared by our methods are being used to assess the physical and biological
properties of these new materials with the aim of applying this knowledge
to design improved materials. Toward building arrays, we develop methods
of nanofabrication based upon the assembly of functionalized nanoparticles.
One method, biomolecular nanolithography, involves self-assembly of nanoparticles
onto biopolymeric (DNA) scaffolds to form lines and more complex patterns.
One potential application of these methods is the generation of molecularly
integrated nanocircuits as a higher performance (and greener) approach in
the microelectronics industry.
Conformationally Preorganized Malonamides
as Ligands and Materials for F-Block Ion Chemistry
Designing effective metal ion receptors is an important challenge in inorganic
and supramolecular chemistry. In addition to improving our understanding
of ion-receptor interactions, such studies lead to new receptors that are
useful in applications that involve sensing, separating, sequestering, and
delivering metal ions. We recently discovered that by “preorganizing”
a malonamide ligand so that the donor groups are ideally positioned for
binding, a 10 million-fold enhancement in binding for f-block ions is achieved.
We are exploring the coordination chemistry of this new ligand class and
using the members of this class as building blocks for the preparation of
functional materials, including membrane-based separations, ion-sensitive
surfaces, polymeric ion sequestering agents and sensors.
Organic Monolayers on Metal and Oxide Surfaces
Organic thin films on surfaces are important model systems for studying
interfacial phenomena and have a number of important applications in fields
ranging from materials science to biomedicine. Self-assembled monolayers
(SAMs) are formed by adsorption of molecules onto surfaces to yield a single
molecular layer. We pioneered the study of amide-containing monolayers wherein
lateral hydrogen bonding between the molecules occurs in the plane of the
SAM. By designing molecules with specific hydrogen-bonding sequences, we
can control the structure, stability and electronic properties of the SAM.
In the case of mixed monolayers, we have used hydrogen bonding to drive
nanoscale patterning of the surface through phase separation. Currently
we are designing new adsorbate molecules through which we can systematically
control nanoscale patterning and chemical gradients on metal and oxide surfaces
and introduce chemical functionality to control the interactions of biomolecules
with these surfaces.
Selected Publications:
53. Lumetta, G.J.; Rapko, B.M.; Garza, P.A.; Hay, B.P.; Gilbertson, R.D.;
Hutchison, J.E. “Deliberate Design of Ligand Architecture Yields Dramatic
Enhancement of Metal Ion Affinity,” J. Am. Chem. Soc. 2002,
124, 5644-5645. Highlighted in Science Magazine as an Editors'
Choice article "Designer Bindings" (2002, 296, 985) and in Chemical
and Engineering News as a Science Concentrate "Designed Ligands Boost
Metal Binding" (2002, 80(20), 37). Also highlighted on the Department
of Energy Office of Science homepage.
59. Warner, M. G.; Hutchison, J. E. "Formation of linear and branched nanoassemblies of gold nanoparticles by electrostatic assembly in solution on DNA scaffolds," Nat. Mater. 2003, 2, 272-276. Highlighted in News and Views in Nature Materials 2003, 2, 214-215.
64. Woehrle, G. H.; Warner, M. G.; Hutchison, J. E. “Molecular-Level Control of Feature Separation in One-Dimensional Nanostructure Assemblies Formed by Biomolecular Nanolithography,” Langmuir 2004, 20, 5982-5988.
68. McKenzie, L. C.; Hutchison, J. E. "Green nanoscience: An integrated approach to greener products, processes, and applications," Chemistry Today 2004, 30-33. September 2004 issue.
70. Woehrle, G.H.; Brown, L.O.; Hutchison, J.E. “Thiol-Functionalized, 1.5-nm Gold Nanoparticles through Ligand Exchange Reactions: Scope and Mechanism of Ligand Exchange,” J. Am. Chem. Soc. 2005, 127, 2172 - 2183.
72. Chambers, R.C.; Inman, C.E.; Hutchison, J.E. “Electrochemical detection of nanoscale phase separation in binary self-assembled monolayers,” Langmuir 2005, 4615-4621.
To Contact Dr. Hutchison:
Phone: 541-346-4228
hutch@uoregon.edu
WEBMASTER
lynde@uoregon.edu
